From Screening to Production: a Holistic Approach of High-throughput Modelbased Bioprocess Development. A significantly more efficient development of bioprocesses can only be achieved through a higher degree of automation and digitalisation.

1. With the ultimate goal of generating a digital twin that describes the dynamics of the cell system across scales;
2. informative experiments (often fed-batch high-cell-density cultivations) must be optimally designed on a parallel scale;
3. these experiments need to be optimally operated with advanced control tools, and combined with comprehensive process analytics, which in turn; 
4. require automated operation of complex robotic systems running difficult nonlinear dynamic bioreactor processes.

In the KIWI-biolab, we integrate these sub-strategies using process control and optimization, AI and machine learning and demonstrate the advantages on different microbial bioprocesses to produce recombinant proteins.

Technische Universität Berlin, Germany:

• Peter Neubauer
• Mariano Nicolas Cruz Bournazou